Moreover, the limit of detection values obtained from the qualitative screening of street drugs were of ppb level, indicating high sensitivity of DART-MS. The examinations of fire accelerants predominantly used the positive ionization mode in the LRMS technique. Drugs, inks, dyes, and paints were mainly analyzed using the positive ionization mode in the HRMS technique.
The review follows that the high-resolution mass-spectrometers or low-resolution mass-spectrometers systems in the positive or negative mode were highly dependent on the type of analyte under investigation. The paper also presents the relation between the type of DART-MS technique and the ionization mode used for a particular class of compounds. The applications include analysis of drugs, warfare agents, gun-shot residues, ink differentiation, and other forensically relevant samples. This review summarizes the applications of DART-MS in the field of Forensic Science reported from 2005 to 2021. This article gives insight into the ionization mechanisms, data analysis tools, and the use of hyphenated techniques like thermal-desorption-DART-MS, infrared-thermal-desorption-DART-MS, Joule-heating thermal-desorption-DART-MS, etc. Its use for chemical analysis credits its ability to analyze the sample at atmospheric pressure. DART-MS is a relatively new technique for rapid mass spectral analysis. Due to such needs, the forensic community is consistently working on broadening the usage of direct analysis in real-time mass spectrometry (DART-MS). The availability of a limited number of seized samples makes it crucial to directly analyze the sample, thereby preventing wastage in the prior steps of sample preparation. As the rate of crime is constantly increasing, the workload on the forensic analyst also piles up.
0 kommentar(er)
